My CD Drive stoped responding

[Jaged]

I was happily playing Doom 3 when the computer locks up I reboot, and when I get back to the desktop I can't get my CD drive to respond to anything. Clicking on the icon for Doom gets a "Please insert DVD-ROM into drive and restart aplication." (I I have the CD version of the game, wtf?) The CD drive dosen't appear on the "My Computer" menu. I haven't tryed any other games or apps yet but I am prety sure they won't work. If they work I will post it here. What is going on? All the cables are pluged in, I already checked that. And I have rebooted 2-3 times.